Antigen affinity and antigen dose exert distinct influences on CD4 T-cell differentiation

Cumulative T-cell receptor signal strength and ensuing T-cell responses are affected by both antigen affinity and antigen dose. Here we examined the distinct contributions of these parameters to CD4 T-cell differentiation during infection. We found that high antigen affinity positively correlates wi...

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Bibliografiske detaljer
Main Authors: Keck, Simone, Schmaler, Mathias, Ganter, Stefan, Wyss, Lena, Oberle, Susanne, Huseby, Eric S., Zehn, Dietmar, King, Carolyn G.
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2014
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4205596/
https://ncbi.nlm.nih.gov/pubmed/25267612
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1403271111
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