T Cell Affinity Regulates Asymmetric Division, Effector Cell Differentiation, and Tissue Pathology

The strength of interactions between T cell receptors and the peptide-major histocompatibility complex (pMHC) directly modulates T cell fitness, clonal expansion, and acquisition of effector properties. Here we show that asymmetric T cell division is an important mechanistic link between increased s...

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Bibliographic Details
Main Authors: King, Carolyn G., Koehli, Sabrina, Hausmann, Barbara, Schmaler, Mathias, Zehn, Dietmar, Palmer, Ed
Format: Artigo
Language:Inglês
Published: 2012
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3622938/
https://ncbi.nlm.nih.gov/pubmed/23084359
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.immuni.2012.06.021
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