Dynamics of the Coreceptor-LCK Interactions during T Cell Development Shape the Self-Reactivity of Peripheral CD4 and CD8 T Cells

Overtly self-reactive T cells are removed during thymic selection. However, it has been recently established that T cell self-reactivity promotes protective immune responses. Apparently, the level of self-reactivity of mature T cells must be tightly balanced. Our mathematical model and experimental...

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Vydáno v:Cell Rep
Hlavní autoři: Horkova, Veronika, Drobek, Ales, Mueller, Daniel, Gubser, Celine, Niederlova, Veronika, Wyss, Lena, King, Carolyn G., Zehn, Dietmar, Stepanek, Ondrej
Médium: Artigo
Jazyk:Inglês
Vydáno: Cell Press 2019
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7003063/
https://ncbi.nlm.nih.gov/pubmed/32023465
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2020.01.008
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