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Inhibitory Receptor Expression Depends More Dominantly on Differentiation and Activation than “Exhaustion” of Human CD8 T Cells

Under conditions of chronic antigen stimulation, such as persistent viral infection and cancer, CD8 T cells may diminish effector function, which has been termed “exhaustion.” Expression of inhibitory Receptors (iRs) is often regarded as a hallmark of “exhaustion.” Here we studied the expression of...

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Detalhes bibliográficos
Main Authors: Legat, Amandine, Speiser, Daniel E., Pircher, Hanspeter, Zehn, Dietmar, Fuertes Marraco, Silvia A.
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3867683/
https://ncbi.nlm.nih.gov/pubmed/24391639
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2013.00455
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