Exhaustion of tumor-specific CD8(+) T cells in metastases from melanoma patients

In chronic viral infections, CD8(+) T cells become functionally deficient and display multiple molecular alterations. In contrast, only little is known of self- and tumor-specific CD8(+) T cells from mice and humans. Here we determined molecular profiles of tumor-specific CD8(+) T cells from melanom...

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Main Authors: Baitsch, Lukas, Baumgaertner, Petra, Devêvre, Estelle, Raghav, Sunil K., Legat, Amandine, Barba, Leticia, Wieckowski, Sébastien, Bouzourene, Hanifa, Deplancke, Bart, Romero, Pedro, Rufer, Nathalie, Speiser, Daniel E.
Format: Artigo
Jezik:Inglês
Izdano: American Society for Clinical Investigation 2011
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3104769/
https://ncbi.nlm.nih.gov/pubmed/21555851
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI46102
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