Autoimmune-associated PTPN22 R620W Variation Reduces Phosphorylation of Lymphoid Phosphatase on an Inhibitory Tyrosine Residue

A missense C1858T single nucleotide polymorphism in the PTPN22 gene recently emerged as a major risk factor for human autoimmunity. PTPN22 encodes the lymphoid tyrosine phosphatase (LYP), which forms a complex with the kinase Csk and is a critical negative regulator of signaling through the T cell r...

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Main Authors: Fiorillo, Edoardo, Orrú, Valeria, Stanford, Stephanie M., Liu, Yingge, Salek, Mogjiborahman, Rapini, Novella, Schenone, Aaron D., Saccucci, Patrizia, Delogu, Lucia G., Angelini, Federica, Manca Bitti, Maria Luisa, Schmedt, Christian, Chan, Andrew C., Acuto, Oreste, Bottini, Nunzio
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2010
Fag:
Signal Transduction
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2924087/
https://ncbi.nlm.nih.gov/pubmed/20538612
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.111104
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