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PTPN22: the archetypal non-HLA autoimmunity gene
PTPN22 encodes a tyrosine phosphatase that is expressed by haematopoietic cells and functions as a key regulator of immune homeostasis by inhibiting T-cell receptor signalling and by selectively promoting type I interferon responses after activation of myeloid-cell pattern-recognition receptors. A s...
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| Published in: | Nat Rev Rheumatol |
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| Main Authors: | , |
| Format: | Artigo |
| Language: | Inglês |
| Published: |
2014
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4375551/ https://ncbi.nlm.nih.gov/pubmed/25003765 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nrrheum.2014.109 |
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