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PTPN22: the archetypal non-HLA autoimmunity gene

PTPN22 encodes a tyrosine phosphatase that is expressed by haematopoietic cells and functions as a key regulator of immune homeostasis by inhibiting T-cell receptor signalling and by selectively promoting type I interferon responses after activation of myeloid-cell pattern-recognition receptors. A s...

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Bibliografische gegevens
Gepubliceerd in:Nat Rev Rheumatol
Hoofdauteurs: Stanford, Stephanie M., Bottini, Nunzio
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2014
Onderwerpen:
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4375551/
https://ncbi.nlm.nih.gov/pubmed/25003765
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nrrheum.2014.109
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