The Autoimmunity-Associated Gene PTPN22 Potentiates Toll-like Receptor-Driven, Type 1 Interferon-Dependent Immunity

Immune cells sense microbial products through Toll-like receptors (TLR), which trigger host defense responses including type 1 interferons (IFNs) secretion. A coding polymorphism in the protein tyrosine phosphatase nonreceptor type 22 (PTPN22) gene is a susceptibility allele for human autoimmune and...

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Main Authors: Wang, Yaya, Shaked, Iftach, Stanford, Stephanie M., Zhou, Wenbo, Curtsinger, Julie M., Mikulski, Zbigniew, Shaheen, Zachary R., Cheng, Genhong, Sawatzke, Kristy, Campbell, Amanda M., Auger, Jennifer L., Bilgic, Hatice, Shoyama, Fernanda M., Schmeling, David O., Balfour, Henry H., Hasegawa, Kiminori, Chan, Andrew C., Corbett, John A., Binstadt, Bryce A., Mescher, Matthew F., Ley, Klaus, Bottini, Nunzio, Peterson, Erik J.
Format: Artigo
Language:Inglês
Published: 2013
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3830738/
https://ncbi.nlm.nih.gov/pubmed/23871208
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.immuni.2013.06.013
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