PTPN22 alters the development of T regulatory cells in the thymus

PTPN22 encodes a tyrosine phosphatase that inhibits Src-family kinases responsible for antigen receptor signaling in lymphocytes, and is strongly linked with susceptibility to a number of autoimmune diseases. As strength of TCR signal is critical to the thymic selection of regulatory T cells (Tregs)...

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Main Authors: Maine, Christian J., Hamilton-Williams, Emma E., Cheung, Jocelyn, Stanford, Stephanie M., Bottini, Nunzio, Wicker, Linda S., Sherman, Linda A.
Format: Artigo
Sprog:Inglês
Udgivet: 2012
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3358490/
https://ncbi.nlm.nih.gov/pubmed/22539785
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1200150
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