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PTPN22 contributes to exhaustion of T lymphocytes during chronic viral infection

The protein encoded by the autoimmune-associated protein tyrosine phosphatase nonreceptor type 22 gene, PTPN22, has wide-ranging effects in immune cells including suppression of T-cell receptor signaling and promoting efficient production of type I interferons (IFN-I) by myeloid cells. Here we show...

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書目詳細資料
發表在:Proc Natl Acad Sci U S A
Main Authors: Maine, Christian J., Teijaro, John R., Marquardt, Kristi, Sherman, Linda A.
格式: Artigo
語言:Inglês
出版: National Academy of Sciences 2016
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC5135306/
https://ncbi.nlm.nih.gov/pubmed/27799548
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1603738113
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