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PTPN22 contributes to exhaustion of T lymphocytes during chronic viral infection
The protein encoded by the autoimmune-associated protein tyrosine phosphatase nonreceptor type 22 gene, PTPN22, has wide-ranging effects in immune cells including suppression of T-cell receptor signaling and promoting efficient production of type I interferons (IFN-I) by myeloid cells. Here we show...
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| Gepubliceerd in: | Proc Natl Acad Sci U S A |
|---|---|
| Hoofdauteurs: | , , , |
| Formaat: | Artigo |
| Taal: | Inglês |
| Gepubliceerd in: |
National Academy of Sciences
2016
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| Onderwerpen: | |
| Online toegang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5135306/ https://ncbi.nlm.nih.gov/pubmed/27799548 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1603738113 |
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