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IL2Rβ-dependent signals drive terminal exhaustion and suppress memory development during chronic viral infection
Exhaustion of CD8(+) T cells severely impedes the adaptive immune response to chronic viral infections. Despite major advances in our understanding of the molecular regulation of exhaustion, the cytokines that directly control this process during chronicity remain unknown. We demonstrate a direct im...
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| Publicat a: | Proc Natl Acad Sci U S A |
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| Autors principals: | , , , , , , , , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
National Academy of Sciences
2016
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5027416/ https://ncbi.nlm.nih.gov/pubmed/27573835 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1604256113 |
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