IL2Rβ-dependent signals drive terminal exhaustion and suppress memory development during chronic viral infection

Exhaustion of CD8(+) T cells severely impedes the adaptive immune response to chronic viral infections. Despite major advances in our understanding of the molecular regulation of exhaustion, the cytokines that directly control this process during chronicity remain unknown. We demonstrate a direct im...

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Foilsithe in:Proc Natl Acad Sci U S A
Main Authors: Beltra, Jean-Christophe, Bourbonnais, Sara, Bédard, Nathalie, Charpentier, Tania, Boulangé, Moana, Michaud, Eva, Boufaied, Ines, Bruneau, Julie, Shoukry, Naglaa H., Lamarre, Alain, Decaluwe, Hélène
Formáid: Artigo
Teanga:Inglês
Foilsithe: National Academy of Sciences 2016
Ábhair:
PNAS Plus
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5027416/
https://ncbi.nlm.nih.gov/pubmed/27573835
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1604256113
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