IL2Rβ-dependent signals drive terminal exhaustion and suppress memory development during chronic viral infection

Exhaustion of CD8(+) T cells severely impedes the adaptive immune response to chronic viral infections. Despite major advances in our understanding of the molecular regulation of exhaustion, the cytokines that directly control this process during chronicity remain unknown. We demonstrate a direct im...

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Dades bibliogràfiques
Publicat a:Proc Natl Acad Sci U S A
Autors principals: Beltra, Jean-Christophe, Bourbonnais, Sara, Bédard, Nathalie, Charpentier, Tania, Boulangé, Moana, Michaud, Eva, Boufaied, Ines, Bruneau, Julie, Shoukry, Naglaa H., Lamarre, Alain, Decaluwe, Hélène
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 2016
Matèries:
PNAS Plus
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5027416/
https://ncbi.nlm.nih.gov/pubmed/27573835
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1604256113
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