IL2Rβ-dependent signals drive terminal exhaustion and suppress memory development during chronic viral infection

Exhaustion of CD8(+) T cells severely impedes the adaptive immune response to chronic viral infections. Despite major advances in our understanding of the molecular regulation of exhaustion, the cytokines that directly control this process during chronicity remain unknown. We demonstrate a direct im...

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Publicado en:Proc Natl Acad Sci U S A
Autores principales: Beltra, Jean-Christophe, Bourbonnais, Sara, Bédard, Nathalie, Charpentier, Tania, Boulangé, Moana, Michaud, Eva, Boufaied, Ines, Bruneau, Julie, Shoukry, Naglaa H., Lamarre, Alain, Decaluwe, Hélène
Formato: Artigo
Lenguaje:Inglês
Publicado: National Academy of Sciences 2016
Materias:
PNAS Plus
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5027416/
https://ncbi.nlm.nih.gov/pubmed/27573835
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1604256113
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