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IL2Rβ-dependent signals drive terminal exhaustion and suppress memory development during chronic viral infection
Exhaustion of CD8(+) T cells severely impedes the adaptive immune response to chronic viral infections. Despite major advances in our understanding of the molecular regulation of exhaustion, the cytokines that directly control this process during chronicity remain unknown. We demonstrate a direct im...
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| Publicado no: | Proc Natl Acad Sci U S A |
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| Main Authors: | , , , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5027416/ https://ncbi.nlm.nih.gov/pubmed/27573835 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1604256113 |
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