The Effect of the Autoimmunity-Associated Gene, PTPN22, on the BXSB Model of Lupus

A single nucleotide polymorphism in PTPN22 is linked to increased disease susceptibility in a range of autoimmune diseases including systemic lupus erythematosus (SLE). PTPN22 encodes the Lyp phosphatase that dampens TCR signaling and is necessary for signaling downstream of toll-like receptors in m...

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Bibliographic Details
Published in:Clin Immunol
Main Authors: Maine, Christian J., Marquardt, Kristi, Scatizzi, John C., Pollard, K. Michael, Kono, Dwight H., Sherman, Linda A.
Format: Artigo
Language:Inglês
Published: 2014
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4291082/
https://ncbi.nlm.nih.gov/pubmed/25463433
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.clim.2014.11.003
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