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PTPN22 alters the development of T regulatory cells in the thymus
PTPN22 encodes a tyrosine phosphatase that inhibits Src-family kinases responsible for antigen receptor signaling in lymphocytes, and is strongly linked with susceptibility to a number of autoimmune diseases. As strength of TCR signal is critical to the thymic selection of regulatory T cells (Tregs)...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
2012
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3358490/ https://ncbi.nlm.nih.gov/pubmed/22539785 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1200150 |
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