The Autoimmunity Risk Variant LYP-W620 Cooperates with CSK in the Regulation of TCR Signaling

The protein tyrosine phosphatase LYP, a key regulator of TCR signaling, presents a single nucleotide polymorphism, C1858T, associated with several autoimmune diseases such as type I diabetes, rheumatoid arthritis, and lupus. This polymorphism changes an R by a W in the P1 Pro rich motif of LYP, whic...

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Autors principals: de la Puerta, María Luisa, Trinidad, Antonio G., Rodríguez, María del Carmen, de Pereda, José María, Sánchez Crespo, Mariano, Bayón, Yolanda, Alonso, Andrés
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2013
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3554717/
https://ncbi.nlm.nih.gov/pubmed/23359562
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0054569
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