Overexpression of the PTPN22 Autoimmune Risk Variant LYP-620W Fails to Restrain Human CD4(+) T Cell Activation

A missense mutation (R620W) of Protein Tyrosine Phosphatase, non-receptor type 22 (PTPN22), which encodes Lymphoid-tyrosine Phosphatase (LYP), confers genetic risk for multiple autoimmune diseases including type 1 diabetes (T1D). LYP has been putatively demonstrated to attenuate proximal T and B cel...

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Publicado no:J Immunol
Main Authors: Perry, Daniel J., Peters, Leeana D., Lakshmi, Priya Saikumar, Zhang, Lin, Han, Zhao, Wasserfall, Clive H., Mathews, Clayton E., Atkinson, Mark A., Brusko, Todd M.
Formato: Artigo
Idioma:Inglês
Publicado em: 2021
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8323970/
https://ncbi.nlm.nih.gov/pubmed/34301848
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.2000708
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