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Overexpression of the PTPN22 Autoimmune Risk Variant LYP-620W Fails to Restrain Human CD4(+) T Cell Activation
A missense mutation (R620W) of Protein Tyrosine Phosphatase, non-receptor type 22 (PTPN22), which encodes Lymphoid-tyrosine Phosphatase (LYP), confers genetic risk for multiple autoimmune diseases including type 1 diabetes (T1D). LYP has been putatively demonstrated to attenuate proximal T and B cel...
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| Pubblicato in: | J Immunol |
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| Autori principali: | , , , , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2021
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8323970/ https://ncbi.nlm.nih.gov/pubmed/34301848 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.2000708 |
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