Autoimmunity-Associated LYP-W620 Does Not Impair Thymic Negative Selection of Autoreactive T Cells

A C1858T (R620W) variation in the PTPN22 gene encoding the tyrosine phosphatase LYP is a major risk factor for human autoimmunity. LYP is a known negative regulator of signaling through the T cell receptor (TCR), and murine Ptpn22 plays a role in thymic selection. However, the mechanism of action of...

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Αποθηκεύτηκε σε:
Λεπτομέρειες βιβλιογραφικής εγγραφής
Κύριοι συγγραφείς: Wu, Dennis J., Zhou, Wenbo, Enouz, Sarah, Orrú, Valeria, Stanford, Stephanie M., Maine, Christian J., Rapini, Novella, Sawatzke, Kristy, Engel, Isaac, Fiorillo, Edoardo, Sherman, Linda A., Kronenberg, Mitch, Zehn, Dietmar, Peterson, Erik, Bottini, Nunzio
Μορφή: Artigo
Γλώσσα:Inglês
Έκδοση: Public Library of Science 2014
Θέματα:
Research Article
Διαθέσιμο Online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3911918/
https://ncbi.nlm.nih.gov/pubmed/24498279
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0086677
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