Ion channel TRPV1-dependent activation of PTP1B suppresses EGFR-associated intestinal tumorigenesis

The intestinal epithelium has a high rate of turnover, and dysregulation of pathways that regulate regeneration can lead to tumor development; however, the negative regulators of oncogenic events in the intestinal epithelium are not fully understood. Here we identified a feedback loop between the ep...

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Autori principali: de Jong, Petrus R., Takahashi, Naoki, Harris, Alexandra R., Lee, Jihyung, Bertin, Samuel, Jeffries, James, Jung, Michael, Duong, Jen, Triano, Amy I., Lee, Jongdae, Niv, Yaron, Herdman, David S., Taniguchi, Koji, Kim, Chang-Whan, Dong, Hui, Eckmann, Lars, Stanford, Stephanie M., Bottini, Nunzio, Corr, Maripat, Raz, Eyal
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Clinical Investigation 2014
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4151223/
https://ncbi.nlm.nih.gov/pubmed/25083990
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI72340
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