Signal Transducer and Activator of Transcription 3 (STAT3) Protein Suppresses Adenoma-to-carcinoma Transition in Apc(min)(/+) Mice via Regulation of Snail-1 (SNAI) Protein Stability

STAT3 was recently reported to suppress tumor invasion in Apc(min)(/+) mice. We investigated the mechanisms by which STAT3 inhibits intestinal epithelial tumors using Apc(min)(/+)/Stat3(IEC-KO) mice (intestinal epithelial cell (IEC)-specific deletion of STAT3 in the Apc(min)(/+) background) to deter...

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Détails bibliographiques
Auteurs principaux: Lee, Jongdae, Kim, Joanna C. K., Lee, Shee-Eun, Quinley, Christine, Kim, HyeRi, Herdman, Scott, Corr, Maripat, Raz, Eyal
Format: Artigo
Langue:Inglês
Publié: American Society for Biochemistry and Molecular Biology 2012
Sujets:
Molecular Bases of Disease
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3365759/
https://ncbi.nlm.nih.gov/pubmed/22496368
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.328831
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