OGA heterozygosity suppresses intestinal tumorigenesis in Apc(min/+) mice

Emerging evidence suggests that aberrant O-GlcNAcylation is associated with tumorigenesis. Many oncogenic factors are O-GlcNAcylated, which modulates their functions. However, it remains unclear how O-GlcNAcylation and O-GlcNAc cycling enzymes, O-GlcNAc transferase (OGT) and O-GlcNAcase (OGA), affec...

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Autors principals: Yang, Y R, Jang, H-J, Yoon, S, Lee, Y H, Nam, D, Kim, I S, Lee, H, Kim, H, Choi, J H, Kang, B H, Ryu, S H, Suh, P-G
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group 2014
Matèries:
Short Communication
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4150210/
https://ncbi.nlm.nih.gov/pubmed/25000257
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/oncsis.2014.24
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