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OGA heterozygosity suppresses intestinal tumorigenesis in Apc(min/+) mice
Emerging evidence suggests that aberrant O-GlcNAcylation is associated with tumorigenesis. Many oncogenic factors are O-GlcNAcylated, which modulates their functions. However, it remains unclear how O-GlcNAcylation and O-GlcNAc cycling enzymes, O-GlcNAc transferase (OGT) and O-GlcNAcase (OGA), affec...
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| Главные авторы: | , , , , , , , , , , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
Nature Publishing Group
2014
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4150210/ https://ncbi.nlm.nih.gov/pubmed/25000257 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/oncsis.2014.24 |
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