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ERK activation drives intestinal tumorigenesis in Apc(min/)(+) mice
TLR signaling is essential for intestinal tumorigenesis in Apc(min/)(+) mice, but the mechanisms by which this protein enhances tumor growth are unknown. Here we show that the Microflora-MyD88-ERK signaling in intestinal epithelial cells (IEC) promotes tumorigenesis by increasing the stability of th...
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| 主要な著者: | , , , , , , , , , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
2010
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2882530/ https://ncbi.nlm.nih.gov/pubmed/20473309 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nm.2143 |
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