ERK activation drives intestinal tumorigenesis in Apc(min/)(+) mice

TLR signaling is essential for intestinal tumorigenesis in Apc(min/)(+) mice, but the mechanisms by which this protein enhances tumor growth are unknown. Here we show that the Microflora-MyD88-ERK signaling in intestinal epithelial cells (IEC) promotes tumorigenesis by increasing the stability of th...

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Bibliografske podrobnosti
Main Authors: Lee, Sung Hee, Hu, Li-Li, Gonzalez-Navajas, Jose, Seo, Geom Seog, Shen, Carol, Brick, Jonathan, Herdman, Scott, Varki, Nissi, Corr, Maripat, Lee, Jongdae, Raz, Eyal
Format: Artigo
Jezik:Inglês
Izdano: 2010
Teme:
Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2882530/
https://ncbi.nlm.nih.gov/pubmed/20473309
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nm.2143
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