Autophagy Suppresses Interleukin-1β (IL-1β) Signaling by Activation of p62 Degradation via Lysosomal and Proteasomal Pathways

ATG16L1 is an essential component of the autophagasome. The T300A allele of ATG16L1 is associated with the increased susceptibility to Crohn disease. In this study, we identified a novel function of ATG16L1, which suppresses signaling of the pro-inflammatory cytokine IL-1β. Deletion of ATG16L1 in mo...

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Detalhes bibliográficos
Main Authors: Lee, Jongdae, Kim, Hye Ri, Quinley, Christine, Kim, Joanna, Gonzalez-Navajas, Jose, Xavier, Ramnik, Raz, Eyal
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2012
Assuntos:
Signal Transduction
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3281713/
https://ncbi.nlm.nih.gov/pubmed/22167182
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.280065
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