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Dynamics of the Degradation of Ubiquitinated Proteins by Proteasomes and Autophagy: ASSOCIATION WITH SEQUESTOSOME 1/p62

Proteotoxicity resulting from accumulation of damaged/unwanted proteins contributes prominently to cellular aging and neurodegeneration. Proteasomal removal of these proteins upon covalent polyubiquitination is highly regulated. Recent reports proposed a role for autophagy in clearance of diffuse ub...

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Detalhes bibliográficos
Main Authors: Myeku, Natura, Figueiredo-Pereira, Maria E.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2011
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3121389/
https://ncbi.nlm.nih.gov/pubmed/21536669
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.149252
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