Sequestosome 1/p62 Is a Polyubiquitin Chain Binding Protein Involved in Ubiquitin Proteasome Degradation

Herein, we demonstrate that the ubiquitin-associated (UBA) domain of sequestosome 1/p62 displays a preference for binding K63-polyubiquitinated substrates. Furthermore, the UBA domain of p62 was necessary for aggregate sequestration and cell survival. However, the inhibition of proteasome function c...

Popoln opis

Shranjeno v:
Bibliografske podrobnosti
Main Authors: Seibenhener, M. Lamar, Babu, Jeganathan Ramesh, Geetha, Thangiah, Wong, Hing C., Krishna, N. Rama, Wooten, Marie W.
Format: Artigo
Jezik:Inglês
Izdano: American Society for Microbiology 2004
Teme:
Cell Growth and Development
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC515032/
https://ncbi.nlm.nih.gov/pubmed/15340068
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.24.18.8055-8068.2004
Oznake: Označite
Brez oznak, prvi označite!

Podobne knjige/članki