Sequestosome 1/p62 Is a Polyubiquitin Chain Binding Protein Involved in Ubiquitin Proteasome Degradation

Herein, we demonstrate that the ubiquitin-associated (UBA) domain of sequestosome 1/p62 displays a preference for binding K63-polyubiquitinated substrates. Furthermore, the UBA domain of p62 was necessary for aggregate sequestration and cell survival. However, the inhibition of proteasome function c...

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Detalhes bibliográficos
Main Authors: Seibenhener, M. Lamar, Babu, Jeganathan Ramesh, Geetha, Thangiah, Wong, Hing C., Krishna, N. Rama, Wooten, Marie W.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2004
Assuntos:
Cell Growth and Development
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC515032/
https://ncbi.nlm.nih.gov/pubmed/15340068
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.24.18.8055-8068.2004
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