Autophagy Suppresses Interleukin-1β (IL-1β) Signaling by Activation of p62 Degradation via Lysosomal and Proteasomal Pathways

ATG16L1 is an essential component of the autophagasome. The T300A allele of ATG16L1 is associated with the increased susceptibility to Crohn disease. In this study, we identified a novel function of ATG16L1, which suppresses signaling of the pro-inflammatory cytokine IL-1β. Deletion of ATG16L1 in mo...

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Hlavní autoři: Lee, Jongdae, Kim, Hye Ri, Quinley, Christine, Kim, Joanna, Gonzalez-Navajas, Jose, Xavier, Ramnik, Raz, Eyal
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2012
Témata:
Signal Transduction
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3281713/
https://ncbi.nlm.nih.gov/pubmed/22167182
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.280065
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