The TRPA1 ion channel is expressed in CD4(+) T cells and restrains T cell-mediated colitis through inhibition of TRPV1

OBJECTIVE: Transient Receptor Potential Ankyrin-1 (TRPA1) and Vanilloid-1 (TRPV1) are calcium (Ca(2+))-permeable ion channels mostly known as pain receptors in sensory neurons. However, growing evidence suggests their crucial involvement in the pathogenesis of IBD. We explored the possible contribut...

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Publicado no:Gut
Main Authors: Bertin, Samuel, Aoki-Nonaka, Yukari, Lee, Jihyung, de Jong, Petrus R, Kim, Peter, Han, Tiffany, Yu, Timothy, To, Keith, Takahashi, Naoki, Boland, Brigid S, Chang, John T, Ho, Samuel B, Herdman, Scott, Corr, Maripat, Franco, Alessandra, Sharma, Sonia, Dong, Hui, Akopian, Armen N, Raz, Eyal
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5173457/
https://ncbi.nlm.nih.gov/pubmed/27325418
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/gutjnl-2015-310710
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