Discovery of a Novel Series of Inhibitors of Lymphoid Tyrosine Phosphatase with Activity in Human T Cells

The lymphoid tyrosine phosphatase LYP, encoded by the PTPN22 gene, is a critical regulator of signaling in T cells and recently emerged as a candidate target for therapy of autoimmune diseases. Here, by library screening, we identified a series of noncompetitive inhibitors of LYP that showed activit...

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Detalhes bibliográficos
Main Authors: Stanford, Stephanie M., Krishnamurthy, Divya, Falk, Matthew D., Messina, Rossella, Debnath, Bikash, Li, Sheng, Liu, Tong, Kazemi, Roza, Dahl, Russell, He, Yantao, Yu, Xiao, Chan, Andrew C., Zhang, Zhong-Yin, Barrios, Amy M., Woods, Virgil L., Neamati, Nouri, Bottini, Nunzio
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3086468/
https://ncbi.nlm.nih.gov/pubmed/21341673
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm101202j
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