Thiuram Disulfides as Pseudo-irreversible Inhibitors of the Lymphoid Tyrosine Phosphatase

We have screened a small library of thiuram disulfides for inhibition of lymphoid tyrosine phosphatase (LYP) activity. The parent thiuram disulfide, disulfiram, inhibited LYP activity in vitro and in Jurkat T cells whereas diethyldithiocarbamate failed to inihibit LYP at the concentrations tested. C...

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Auteurs principaux: Kulkarni, Rhushikesh A., Stanford, Stephanie M., Vellore, Nadeem A., Krishnamurthy, Divya, Bliss, Matthew R., Baron, Riccardo, Bottini, Nunzio, Barrios, Amy M.
Format: Artigo
Langue:Inglês
Publié: 2013
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3863632/
https://ncbi.nlm.nih.gov/pubmed/23873737
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cmdc.201300215
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