High-throughput screen using a single-cell tyrosine phosphatase assay reveals biologically active inhibitors of tyrosine phosphatase CD45

Many cellular signaling events are regulated by tyrosine phosphorylation and mediated by the opposing actions of protein tyrosine kinases and phosphatases. Protein tyrosine phosphatases are emerging as drug targets, but poor cell permeability of inhibitors has limited the development of drugs target...

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Detalhes bibliográficos
Main Authors: Stanford, Stephanie M., Panchal, Rekha G., Walker, Logan M., Wu, Dennis J., Falk, Matthew D., Mitra, Sayantan, Damle, Sagar S., Ruble, David, Kaltcheva, Teodora, Zhang, Sheng, Zhang, Zhong-Yin, Bavari, Sina, Barrios, Amy M., Bottini, Nunzio
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2012
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3435192/
https://ncbi.nlm.nih.gov/pubmed/22891353
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1205028109
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