High-throughput screen using a single-cell tyrosine phosphatase assay reveals biologically active inhibitors of tyrosine phosphatase CD45

Many cellular signaling events are regulated by tyrosine phosphorylation and mediated by the opposing actions of protein tyrosine kinases and phosphatases. Protein tyrosine phosphatases are emerging as drug targets, but poor cell permeability of inhibitors has limited the development of drugs target...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Stanford, Stephanie M., Panchal, Rekha G., Walker, Logan M., Wu, Dennis J., Falk, Matthew D., Mitra, Sayantan, Damle, Sagar S., Ruble, David, Kaltcheva, Teodora, Zhang, Sheng, Zhang, Zhong-Yin, Bavari, Sina, Barrios, Amy M., Bottini, Nunzio
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: National Academy of Sciences 2012
Pynciau:
Biological Sciences
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC3435192/
https://ncbi.nlm.nih.gov/pubmed/22891353
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1205028109
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