Abnormal PTPN11 enhancer methylation promotes rheumatoid arthritis fibroblast-like synoviocyte aggressiveness and joint inflammation

The PTPN11 gene, encoding the tyrosine phosphatase SHP-2, is overexpressed in rheumatoid arthritis (RA) fibroblast-like synoviocytes (FLS) compared with osteoarthritis (OA) FLS and promotes RA FLS invasiveness. Here, we explored the molecular basis for PTPN11 overexpression in RA FLS and the role of...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:JCI Insight
Egile Nagusiak: Maeshima, Keisuke, Stanford, Stephanie M., Hammaker, Deepa, Sacchetti, Cristiano, Zeng, Li-fan, Ai, Rizi, Zhang, Vida, Boyle, David L., Aleman Muench, German R., Feng, Gen-Sheng, Whitaker, John W., Zhang, Zhong-Yin, Wang, Wei, Bottini, Nunzio, Firestein, Gary S.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: American Society for Clinical Investigation 2016
Gaiak:
Research Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC4889026/
https://ncbi.nlm.nih.gov/pubmed/27275015
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.86580
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