PTPN14 phosphatase and YAP promote TGFβ signaling in rheumatoid synoviocytes

OBJECTIVE: We aimed to understand the role of the tyrosine phosphatase PTPN14 –which in cancer cells modulates the Hippo pathway by retaining YAP in the cytosol- in fibroblast-like synoviocytes (FLS) from rheumatoid arthritis (RA) patients. METHODS: Gene/protein expression levels were measured by qP...

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Veröffentlicht in:Ann Rheum Dis
Hauptverfasser: Bottini, Angel, Wu, Dennis J, Ai, Rizi, Le Roux, Michelle, Bartok, Beatrix, Bombardieri, Michele, Doody, Karen M., Zhang, Vida, Sacchetti, Cristiano, Zoccheddu, Martina, Lonic, Ana, Li, Xiaochun, Boyle, David, Hammaker, Deepa, Meng, Tzu-Ching, Liu, Lin, Corr, Maripat, Stanford, Stephanie M., Lewis, Myles, Wang, Wei, Firestein, Gary S., Khew-Goodall, Yeesim, Pitzalis, Costantino, Bottini, Nunzio
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2019
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7039277/
https://ncbi.nlm.nih.gov/pubmed/30808624
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/annrheumdis-2018-213799
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