Abnormal PTPN11 enhancer methylation promotes rheumatoid arthritis fibroblast-like synoviocyte aggressiveness and joint inflammation

The PTPN11 gene, encoding the tyrosine phosphatase SHP-2, is overexpressed in rheumatoid arthritis (RA) fibroblast-like synoviocytes (FLS) compared with osteoarthritis (OA) FLS and promotes RA FLS invasiveness. Here, we explored the molecular basis for PTPN11 overexpression in RA FLS and the role of...

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Udgivet i:JCI Insight
Main Authors: Maeshima, Keisuke, Stanford, Stephanie M., Hammaker, Deepa, Sacchetti, Cristiano, Zeng, Li-fan, Ai, Rizi, Zhang, Vida, Boyle, David L., Aleman Muench, German R., Feng, Gen-Sheng, Whitaker, John W., Zhang, Zhong-Yin, Wang, Wei, Bottini, Nunzio, Firestein, Gary S.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Clinical Investigation 2016
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4889026/
https://ncbi.nlm.nih.gov/pubmed/27275015
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.86580
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