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PUMA-mediated apoptosis in fibroblast-like synoviocytes does not require p53

PUMA (p53-upregulated modulator of apoptosis) is a pro-apoptotic gene that can induce rapid cell death through a p53-dependent mechanism. However, the efficacy of PUMA gene therapy to induce synovial apoptosis in rheumatoid arthritis might have limited efficacy if p53 expression or function is defic...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: You, Xin, Boyle, David L, Hammaker, Deepa, Firestein, Gary S
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: BioMed Central 2006
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC1794498/
https://ncbi.nlm.nih.gov/pubmed/17014719
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/ar2052
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