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PUMA-mediated apoptosis in fibroblast-like synoviocytes does not require p53

PUMA (p53-upregulated modulator of apoptosis) is a pro-apoptotic gene that can induce rapid cell death through a p53-dependent mechanism. However, the efficacy of PUMA gene therapy to induce synovial apoptosis in rheumatoid arthritis might have limited efficacy if p53 expression or function is defic...

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Hlavní autoři: You, Xin, Boyle, David L, Hammaker, Deepa, Firestein, Gary S
Médium: Artigo
Jazyk:Inglês
Vydáno: BioMed Central 2006
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC1794498/
https://ncbi.nlm.nih.gov/pubmed/17014719
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/ar2052
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