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PUMA-mediated apoptosis in fibroblast-like synoviocytes does not require p53
PUMA (p53-upregulated modulator of apoptosis) is a pro-apoptotic gene that can induce rapid cell death through a p53-dependent mechanism. However, the efficacy of PUMA gene therapy to induce synovial apoptosis in rheumatoid arthritis might have limited efficacy if p53 expression or function is defic...
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| Autors principals: | , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
BioMed Central
2006
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1794498/ https://ncbi.nlm.nih.gov/pubmed/17014719 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/ar2052 |
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