A High Content Imaging Assay for Identification of Botulinum Neurotoxin Inhibitors

Por Kota, Krishna P., Soloveva, Veronica, Wanner, Laura M., Gomba, Glenn, Kiris, Erkan, Panchal, Rekha G., Kane, Christopher D., Bavari, Sina
Publicado no J Vis Exp (2014)

Pharmacophore Refinement Guides the Design of Nanomolar-Range Botulinum Neurotoxin Serotype A Light Chain Inhibitors

Por Nuss, Jonathan E., Dong, Yuxiang, Wanner, Laura M., Ruthel, Gordon, Wipf, Peter, Gussio, Rick, Vennerstrom, Jonathan L., Bavari, Sina, Burnett, James C.
Publicado em 2010

Post-Intoxication Inhibition of Botulinum Neurotoxin Serotype A within Neurons by Small-Molecule, Non-Peptidic Inhibitors

Por Ruthel, Gordon, Burnett, James C., Nuss, Jonathan E., Wanner, Laura M., Tressler, Lyal E., Torres-Melendez, Edna, Sandwick, Sarah J., Retterer, Cary J., Bavari, Sina
Publicado em 2011

Embryonic stem cell derived motoneurons provide a highly sensitive cell culture model for botulinum neurotoxin studies, with implications for high-throughput drug discovery

Por Kiris, Erkan, Nuss, Jonathan E., Burnett, James C., Kota, Krishna P., Koh, Dawn C., Wanner, Laura M., Torres-Melendez, Edna, Gussio, Rick, Tessarollo, Lino, Bavari, Sina
Publicado em 2011

Novel Benzimidazole Inhibitors of Botulinum Neurotoxin/A Display Enzyme and Cell-Based Potency

Por Cardinale, Steven C., Butler, Michelle M., Ruthel, Gordon, Nuss, Jonathan E., Wanner, Laura M., Li, Bing, Pai, Ramdas, Peet, Norton P., Bavari, Sina, Bowlin, Terry L.
Publicado em 2011

Src Family Kinase Inhibitors Antagonize the Toxicity of Multiple Serotypes of Botulinum Neurotoxin in Human Embryonic Stem Cell-Derived Motor Neurons

Por Kiris, Erkan, Burnett, James C., Nuss, Jonathan E., Wanner, Laura M., Peyser, Brian D., Du, Hao T., Gomba, Glenn Y., Kota, Krishna P., Panchal, Rekha G., Gussio, Rick, Kane, Christopher D., Tessarollo, Lino, Bavari, Sina
Publicado no Neurotox Res (2015)

Phosphatase Inhibitors Function as Novel, Broad Spectrum Botulinum Neurotoxin Antagonists in Mouse and Human Embryonic Stem Cell-Derived Motor Neuron-Based Assays

Por Kiris, Erkan, Nuss, Jonathan E., Stanford, Stephanie M., Wanner, Laura M., Cazares, Lisa, Maestre, Michael F., Du, Hao T., Gomba, Glenn Y., Burnett, James C., Gussio, Rick, Bottini, Nunzio, Panchal, Rekha G., Kane, Christopher D., Tessarollo, Lino, Bavari, Sina
Publicado no PLoS One (2015)

Multi-Faceted Proteomic Characterization of Host Protein Complement of Rift Valley Fever Virus Virions and Identification of Specific Heat Shock Proteins, Including HSP90, as Impor...

Por Nuss, Jonathan E., Kehn-Hall, Kylene, Benedict, Ashwini, Costantino, Julie, Ward, Michael, Peyser, Brian D., Retterer, Cary J., Tressler, Lyal E., Wanner, Laura M., McGovern, Hugh F., Zaidi, Anum, Anthony, Scott M., Kota, Krishna P., Bavari, Sina, Hakami, Ramin M.
Publicado em 2014