Post-Intoxication Inhibition of Botulinum Neurotoxin Serotype A within Neurons by Small-Molecule, Non-Peptidic Inhibitors

Botulinum neurotoxins (BoNTs) comprise seven distinct serotypes that inhibit the release of neurotransmitter across neuromuscular junctions, resulting in potentially fatal flaccid paralysis. BoNT serotype A (BoNT/A), which targets synaptosomal-associated protein of 25kDa (SNAP-25), is particularly l...

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Main Authors: Ruthel, Gordon, Burnett, James C., Nuss, Jonathan E., Wanner, Laura M., Tressler, Lyal E., Torres-Melendez, Edna, Sandwick, Sarah J., Retterer, Cary J., Bavari, Sina
Format: Artigo
Jezik:Inglês
Izdano: MDPI 2011
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3202822/
https://ncbi.nlm.nih.gov/pubmed/22069707
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/toxins3030207
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