Pharmacophore Refinement Guides the Design of Nanomolar-Range Botulinum Neurotoxin Serotype A Light Chain Inhibitors

[Image: see text] Botulinum neurotoxins (BoNTs) are the deadliest of microbial toxins. The enzymes’ zinc(II) metalloprotease, referred to as the light chain (LC) component, inhibits acetylcholine release into neuromuscular junctions, resulting in the disease botulism. Currently, no therapies counter...

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Bibliografiske detaljer
Main Authors: Nuss, Jonathan E., Dong, Yuxiang, Wanner, Laura M., Ruthel, Gordon, Wipf, Peter, Gussio, Rick, Vennerstrom, Jonathan L., Bavari, Sina, Burnett, James C.
Format: Artigo
Sprog:Inglês
Udgivet: American Chemical Society 2010
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2992458/
https://ncbi.nlm.nih.gov/pubmed/21116458
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ml100056v
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