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Pharmacophore Refinement Guides the Design of Nanomolar-Range Botulinum Neurotoxin Serotype A Light Chain Inhibitors
[Image: see text] Botulinum neurotoxins (BoNTs) are the deadliest of microbial toxins. The enzymes’ zinc(II) metalloprotease, referred to as the light chain (LC) component, inhibits acetylcholine release into neuromuscular junctions, resulting in the disease botulism. Currently, no therapies counter...
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| Główni autorzy: | , , , , , , , , |
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| Format: | Artigo |
| Język: | Inglês |
| Wydane: |
American Chemical Society
2010
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| Dostęp online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2992458/ https://ncbi.nlm.nih.gov/pubmed/21116458 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ml100056v |
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