A High Content Imaging Assay for Identification of Botulinum Neurotoxin Inhibitors

Synaptosomal-associated protein-25 (SNAP-25) is a component of the soluble NSF attachment protein receptor (SNARE) complex that is essential for synaptic neurotransmitter release. Botulinum neurotoxin serotype A (BoNT/A) is a zinc metalloprotease that blocks exocytosis of neurotransmitter by cleavin...

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Detalles Bibliográficos
Publicado en:J Vis Exp
Autores principales: Kota, Krishna P., Soloveva, Veronica, Wanner, Laura M., Gomba, Glenn, Kiris, Erkan, Panchal, Rekha G., Kane, Christopher D., Bavari, Sina
Formato: Artigo
Lenguaje:Inglês
Publicado: MyJove Corporation 2014
Materias:
Neuroscience
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4354101/
https://ncbi.nlm.nih.gov/pubmed/25489815
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3791/51915
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