Src Family Kinase Inhibitors Antagonize the Toxicity of Multiple Serotypes of Botulinum Neurotoxin in Human Embryonic Stem Cell-Derived Motor Neurons

Botulinum neurotoxins (BoNTs), the causative agents of botulism, are potent inhibitors of neurotransmitter release from motor neurons. There are currently no drugs to treat BoNT intoxication after the onset of the disease symptoms. In this study, we explored how modulation of key host pathways affec...

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Publié dans:Neurotox Res
Auteurs principaux: Kiris, Erkan, Burnett, James C., Nuss, Jonathan E., Wanner, Laura M., Peyser, Brian D., Du, Hao T., Gomba, Glenn Y., Kota, Krishna P., Panchal, Rekha G., Gussio, Rick, Kane, Christopher D., Tessarollo, Lino, Bavari, Sina
Format: Artigo
Langue:Inglês
Publié: 2015
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4455898/
https://ncbi.nlm.nih.gov/pubmed/25782580
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s12640-015-9526-z
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