Phosphatase Inhibitors Function as Novel, Broad Spectrum Botulinum Neurotoxin Antagonists in Mouse and Human Embryonic Stem Cell-Derived Motor Neuron-Based Assays

There is an urgent need to develop novel treatments to counter Botulinum neurotoxin (BoNT) poisoning. Currently, the majority of BoNT drug development efforts focus on directly inhibiting the proteolytic components of BoNT, i.e. light chains (LC). Although this is a rational approach, previous resea...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:PLoS One
Prif Awduron: Kiris, Erkan, Nuss, Jonathan E., Stanford, Stephanie M., Wanner, Laura M., Cazares, Lisa, Maestre, Michael F., Du, Hao T., Gomba, Glenn Y., Burnett, James C., Gussio, Rick, Bottini, Nunzio, Panchal, Rekha G., Kane, Christopher D., Tessarollo, Lino, Bavari, Sina
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Public Library of Science 2015
Pynciau:
Research Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC4462581/
https://ncbi.nlm.nih.gov/pubmed/26061731
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0129264
Tagiau: Ychwanegu Tag
Dim Tagiau, Byddwch y cyntaf i dagio'r cofnod hwn!

Eitemau Tebyg