Phosphatase Inhibitors Function as Novel, Broad Spectrum Botulinum Neurotoxin Antagonists in Mouse and Human Embryonic Stem Cell-Derived Motor Neuron-Based Assays

There is an urgent need to develop novel treatments to counter Botulinum neurotoxin (BoNT) poisoning. Currently, the majority of BoNT drug development efforts focus on directly inhibiting the proteolytic components of BoNT, i.e. light chains (LC). Although this is a rational approach, previous resea...

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Udgivet i:PLoS One
Main Authors: Kiris, Erkan, Nuss, Jonathan E., Stanford, Stephanie M., Wanner, Laura M., Cazares, Lisa, Maestre, Michael F., Du, Hao T., Gomba, Glenn Y., Burnett, James C., Gussio, Rick, Bottini, Nunzio, Panchal, Rekha G., Kane, Christopher D., Tessarollo, Lino, Bavari, Sina
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2015
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4462581/
https://ncbi.nlm.nih.gov/pubmed/26061731
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0129264
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