PTPome profile of rheumatoid arthritis fibroblast-like synoviocytes: a novel role for SHP-2 as a modulator of invasion and survival

OBJECTIVE: The fibroblast-like synoviocytes (FLS) in the synovial intimal lining of the joint are key mediators of inflammation and joint destruction in rheumatoid arthritis (RA). In RA, these cells aggressively invade the extracellular matrix, producing cartilage-degrading proteases and inflammator...

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Bibliographische Detailangaben
Hauptverfasser: Stanford, Stephanie M., Maestre, Michael F., Campbell, Amanda M., Bartok, Beatrix, Kiosses, William B., Boyle, David L., Arnett, Heather A., Mustelin, Tomas, Firestein, Gary S., Bottini, Nunzio
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2013
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3636201/
https://ncbi.nlm.nih.gov/pubmed/23335101
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/art.37872
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