PTPome profile of rheumatoid arthritis fibroblast-like synoviocytes: a novel role for SHP-2 as a modulator of invasion and survival

OBJECTIVE: The fibroblast-like synoviocytes (FLS) in the synovial intimal lining of the joint are key mediators of inflammation and joint destruction in rheumatoid arthritis (RA). In RA, these cells aggressively invade the extracellular matrix, producing cartilage-degrading proteases and inflammator...

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Main Authors: Stanford, Stephanie M., Maestre, Michael F., Campbell, Amanda M., Bartok, Beatrix, Kiosses, William B., Boyle, David L., Arnett, Heather A., Mustelin, Tomas, Firestein, Gary S., Bottini, Nunzio
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3636201/
https://ncbi.nlm.nih.gov/pubmed/23335101
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/art.37872
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