An old probe sheds new light on BK channel pore structure

Por McManus, Owen B., Rothberg, Brad S.
Publicado no J Gen Physiol (2014)

Mechanism of Maxi-K Channel Activation by Dehydrosoyasaponin-I

Por Giangiacomo, Kathleen M., Kamassah, Augustus, Harris, Guy, McManus, Owen B.
Publicado em 1998

Ion Channels as Drug Targets: The Next GPCRs

Por Kaczorowski, Gregory J., McManus, Owen B., Priest, Birgit T., Garcia, Maria L.
Publicado em 2008

Profiling Diverse Compounds by Flux- and Electrophysiology-Based Primary Screens for Inhibition of Human Ether-à-go-go Related Gene Potassium Channels

Por Zou, Beiyan, Yu, Haibo, Babcock, Joseph J., Chanda, Pritam, Bader, Joel S., McManus, Owen B., Li, Min
Publicado em 2010

Oxidative Regulation of Large Conductance Calcium-Activated Potassium Channels

Por Tang, Xiang D., Daggett, Heather, Hanner, Markus, Garcia, Maria L., McManus, Owen B., Brot, Nathan, Weissbach, Herbert, Heinemann, Stefan H., Hoshi, Toshinori
Publicado em 2001

Discovery of a Series of 2-phenyl-N-(2-(pyrrolidin-1-yl)phenyl)acetamides as Novel Molecular Switches that Modulate Modes of K(v)7.2 (KCNQ2) Channel Pharmacology: Identification of...

Por Cheung, Yiu-Yin, Yu, Haibo, Xu, Kaiping, Zou, Beiyan, Wu, Meng, McManus, Owen B., Li, Min, Lindsley, Craig W., Hopkins, Corey R.
Publicado em 2012

Discovery and characterization of 2-(cyclopropanesulfonamido)-N-(2-ethoxyphenyl)benzamide, ML382: a potent and selective positive allosteric modulator of MrgX1

Por Wen, Wandong, Wang, Yan, Li, Zhe, Tseng, Pang-Yen, McManus, Owen B., Wu, Meng, Li, Min, Lindsley, Craig W., Dong, Xinzhong, Hopkins, Corey R.
Publicado no ChemMedChem (2014)

Discovery, Synthesis, and Structure–Activity Relationship of a Series of N-Aryl-bicyclo[2.2.1]heptane-2-carboxamides: Characterization of ML213 as a Novel KCNQ2 and KCNQ4 Potassium...

Por Yu, Haibo, Wu, Meng, Townsend, Steven D., Zou, Beiyan, Long, Shunyou, Daniels, J. Scott, McManus, Owen B., Li, Min, Lindsley, Craig W., Hopkins, Corey R.
Publicado em 2011

Potent and selective inhibitors of the TASK-1 potassium channel through chemical optimization of a bis-amide scaffold

Por Flaherty, Daniel P., Simpson, Denise S., Miller, Melissa, Maki, Brooks E., Zou, Beiyan, Shi, Jie, Wu, Meng, McManus, Owen B., Aubé, Jeffrey, Li, Min, Golden, Jennifer E.
Publicado em 2014

Biophysical and pharmacological properties of the voltage-gated potassium current of human pancreatic β-cells

Por Herrington, James, Sanchez, Manuel, Wunderler, Denize, Yan, Lizhen, Bugianesi, Randal M, Dick, Ivy E, Clark, Sam A, Brochu, Richard M, Priest, Birgit T, Kohler, Martin G, McManus, Owen B
Publicado em 2005

Dynamic subunit stoichiometry confers a progressive continuum of pharmacological sensitivity by KCNQ potassium channels

Por Yu, Haibo, Lin, Zhihong, Mattmann, Margrith E., Zou, Beiyan, Terrenoire, Cecile, Zhang, Hongkang, Wu, Meng, McManus, Owen B., Kass, Robert S., Lindsley, Craig W., Hopkins, Corey R., Li, Min
Publicado em 2013

Modulation of hERG potassium channel gating normalizes action potential duration prolonged by dysfunctional KCNQ1 potassium channel

Por Zhang, Hongkang, Zou, Beiyan, Yu, Haibo, Moretti, Alessandra, Wang, Xiaoying, Yan, Wei, Babcock, Joseph J., Bellin, Milena, McManus, Owen B., Tomaselli, Gordon, Nan, Fajun, Laugwitz, Karl-Ludwig, Li, Min
Publicado em 2012

Identification and Characterization of ML352: A Novel, Noncompetitive Inhibitor of the Presynaptic Choline Transporter

Por Ennis, Elizabeth A., Wright, Jane, Retzlaff, Cassandra L., McManus, Owen B., Lin, Zhinong, Huang, Xiaofang, Wu, Meng, Li, Min, Daniels, J. Scott, Lindsley, Craig W., Hopkins, Corey R., Blakely, Randy D.
Publicado no ACS Chem Neurosci (2015)

Selective inhibition of the K(ir)2 family of inward rectifier potassium channels by a small molecule probe: the discovery, SAR and pharmacological characterization of ML133

Por Wang, Hao-Ran, Wu, Meng, Yu, Haibo, Long, Shunyou, Stevens, Amy, Engers, Darren W., Sackin, Henry, Daniels, J. Scott, Dawson, Eric S., Hopkins, Corey R., Lindsley, Craig W., Li, Min, McManus, Owen B
Publicado em 2011

Identification of (R)-N-(4-(4-methoxyphenyl)thiazol-2-yl)-1-tosylpiperidine-2-carboxamide, ML277, as a novel, potent and selective K(v)7.1 (KCNQ1) potassium channel activator

Por Mattmann, Margrith E., Yu, Haibo, Lin, Zhihong, Xu, Kaiping, Huang, Xiaofang, Long, Shunyou, Wu, Meng, McManus, Owen B., Engers, Darren W., Le, Uyen M., Li, Min, Lindsley, Craig W., Hopkins, Corey R.
Publicado em 2012

Identification and optimization of 2-aminobenzimidazole derivatives as novel inhibitors of TRPC4 and TRPC5 channels

Por Zhu, Yingmin, Lu, Yungang, Qu, Chunrong, Miller, Melissa, Tian, Jinbin, Thakur, Dhananjay P, Zhu, Jinmei, Deng, Zixin, Hu, Xianming, Wu, Meng, McManus, Owen B, Li, Min, Hong, Xuechuan, Zhu, Michael X, Luo, Huai-Rong
Publicado no Br J Pharmacol (2015)

Asymmetric synthesis and evaluation of a hydroxyphenylamide voltage-gated sodium channel blocker in human prostate cancer xenografts

Por Davis, Gary C., Kong, Yali, Paige, Mikell, Li, Zhang, Merrick, Ellen C., Hansen, Todd, Suy, Simeng, Wang, Kan, Dakshanamurthy, Sivanesan, Cordova, Antoinette, McManus, Owen B., Williams, Brande S., Chruszcz, Maksymilian, Minor, Wladek, Patel, Manoj K., Brown, Milton L.
Publicado em 2011

Improved Ca(v)2.2 Channel Inhibitors through a gem-Dimethylsulfone Bioisostere Replacement of a Labile Sulfonamide

Por Shao, Pengcheng P., Ye, Feng, Chakravarty, Prasun K., Herrington, James B., Dai, Ge, Bugianesi, Randal M., Haedo, Rodolfo J., Swensen, Andrew M., Warren, Vivien A., Smith, McHardy M., Garcia, Maria L., McManus, Owen B., Lyons, Kathryn A., Li, Xiaohua, Green, Mitchell, Jochnowitz, Nina, McGowan, Erin, Mistry, Shruti, Sun, Shu-Yu, Abbadie, Catherine, Kaczorowski, Gregory J., Duffy, Joseph L.
Publicado em 2013