Modulation of hERG potassium channel gating normalizes action potential duration prolonged by dysfunctional KCNQ1 potassium channel

Long QT syndrome (LQTS) is a genetic disease characterized by a prolonged QT interval in an electrocardiogram (ECG), leading to higher risk of sudden cardiac death. Among the 12 identified genes causal to heritable LQTS, ∼90% of affected individuals harbor mutations in either KCNQ1 or human ether-a-...

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Hlavní autoři: Zhang, Hongkang, Zou, Beiyan, Yu, Haibo, Moretti, Alessandra, Wang, Xiaoying, Yan, Wei, Babcock, Joseph J., Bellin, Milena, McManus, Owen B., Tomaselli, Gordon, Nan, Fajun, Laugwitz, Karl-Ludwig, Li, Min
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 2012
Témata:
Biological Sciences
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3406814/
https://ncbi.nlm.nih.gov/pubmed/22745159
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1205266109
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