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Stereoselective Inhibition of the hERG1 Potassium Channel

A growing number of drugs have been shown to prolong cardiac repolarization, predisposing individuals to life-threatening ventricular arrhythmias known as Torsades de Pointes. Most of these drugs are known to interfere with the human ether à-gogo related gene 1 (hERG1) channel, whose current is one...

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Main Authors: Grilo, Liliana Sintra, Carrupt, Pierre-Alain, Abriel, Hugues
Formato: Artigo
Idioma:Inglês
Publicado: Frontiers Research Foundation 2010
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3153011/
https://ncbi.nlm.nih.gov/pubmed/21833176
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2010.00137
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